货号：16-232

品牌：Merck Millipore

规格：100Ug

目录价：￥6742.00

市场价格：￥5730.70

会员价格：￥5393.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-α-Tubulin Antibody, clone DM1A, Alexa Fluor® 488 conjugate | 16-232 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes α-Tubulin, clone DM1A, Mr 50-60 kDa. View All» Molecular Weight: 50-60 kDa View All» Epitope: The epitopehas been mapped to amino acids 426-450 (AALEKDYEEVGVDSV-EGEGEEEGEE). View All» Immunogen: Purified human brain α-Tubulin. The epitope recognized by this antibody has been mapped to amino acids 426-450 (AALEKDYEEVGVDSV-EGEGEEEGEE). View All» Clone: DM1A View All» Isotype: IgG1 View All» Background Information: Tubulins, major components of the cellular cytoskeleton, form microtubules that are critical for cellular structure, migration, cell division and intracellular trafficking. There are at least three types of tubulins, alpha, beta and gamma. Each has a molecular weight of approximately 55 kDa. Microtubules are large structures (300 angstrom diameter) composed of alternating alpha and beta subunits. Compounds that block microtuble formation, such as Taxol and the vinca alkaloids, inhibit cell division and are effective anti-cancer agents. View All» Species Reactivity:

• Human

• Rat

• Guinea Pig

• Bovine

• Mouse

• Pig

• Avian
  View All» Species Reactivity Note: Human, mouse, rat, bovine, porcine, guinea pig and avian. View All» Application Notes: Western Blot Analysis: 2 µg/mL of a previous lot detected α-Tubulin in RIPA lysates from A431 cells.Immunocytochemistry: 2 µg/mL of a previous lot showed positive immunostaining for α-Tubulin in HeLa cells. View All» Control: Included Negative Control: Catalog # 16-240, Normal Mouse IgG, Alexa Fluor® 488-conjugate. View All» Quality Assurance: Routinely evaluated by Flow Cytometry.Flow Cytometry: 0.2 μg of this lot detected α-Tubulin in fixed and permeabilized rat L6, Jurkat, and A431 cells. View All» Purification Method: Protein G purfied View All» Presentation: Alexa Fluor® 488 conjugated, purified mouse monoclonal IgG1 in buffer containing PBS containing 1% BSA, 0.05% Tween®-20, 0.05% sodium azide. Liquid at 2-8°C. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. Do Not Freeze. Do not store the material diluted.For maximum recovery of product, centrifuge original vial prior to removing cap. View All» UniProt Number: Q71U36 View All» Entrez Gene Number: NP_006000 View All» Gene Symbol:
  • TUBA1A

  • B-ALPHA-1

  • FLJ25113

  • hum-a-tub1

  • TUBA3

  • hum-a-tub2
    View All» Alternate Names:
    • Alpha-tubulin 3

    • Tubulin B-alpha-1

    • Tubulin alpha-3 chain

    • tubulin, alpha 1a

    • tubulin, alpha 3

    • tubulin, alpha, brain-specific
      View All» Usage Statement:
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
        View All» Key Applications:
        • Flow Cytometry

        • Immunocytochemistry

        • Immunofluorescence

        • Western Blotting
          View All» Entrez Gene Summary: Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to mouse and rat Tuba1 gene. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q. View All» UniProt Summary: FUNCTION:SwissProt: Q71U36 # Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.SIZE:451 amino acids; 50136 Da SUBUNIT: Dimer of alpha and beta chains.PTM:Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively (By similarity).SIMILARITY:SwissProt: Q71U36 ## Belongs to the tubulin family. View All» Brand Family: Upstate View All» Product Name: Anti-α-Tubulin Antibody, clone DM1A, Alexa Fluor® 488 conjugate | 16-232 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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