货号：16-236

品牌：Merck Millipore

规格：

目录价：￥4755.00

市场价格：￥4041.75

会员价格：￥3804.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor® 555 | 16-236 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: activated form of erbB2/HER-2 oncoprotein View All» Immunogen: Synthetic phosphopeptide, residues 1243-1255, corresponding to a major autophosphorylation (Tyr1248) site of human erbB2/HER-2 (C-AENPEpYLGLDVPV) View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Predicted to cross-react with rat based on conservation of immunogenic sequence View All» Quality Assurance: Routinely evaluated by immunostaining of EGF treated A431 cells View All» Purification Method: Immunoaffinity purified View All» Storage Conditions: 1 year at 4°C from date of shipment View All» UniProt Number: P04626 View All» Entrez Gene Number:
  • NM_001005862.1

  • NM_004448.2
    View All» Gene Symbol:
    • ERBB2

    • HER2

    • HER-2

    • NGL

    • herstatin

    • erbB-2

    • C-erbB-2

    • NEU

    • TKR1

    • p185erbB2

    • HER-2/neu
      View All» Usage Statement:
      • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
        View All» Key Applications:
        • Flow Cytometry

        • Immunocytochemistry
          View All» Entrez Gene Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. View All» UniProt Summary: FUNCTION: SwissProt: P04626 # Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF- alpha and amphiregulin.SIZE: 1255 amino acids; 137910 Da SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.PTM: Ligand-binding increases phosphorylation on tyrosine residues (By similarity).SIMILARITY: SwissProt: P04626 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor® 555 | 16-236 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: AlexaFluor®555 View All» Host: Rabbit View All»
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