货号：16-258

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IRS1 Antibody, Alexa Fluor® 555 conjugate | 16-258 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: IRS1 View All» Molecular Weight: 165 kDa View All» Immunogen: c-terminal 14 amino acid peptide ([C]-ASINFQKQPEDRQ) of rat liver IRS1 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: Routinely evaluated by immunocytochemistry on fixed and permeabilized 3T3 cells View All» Purification Method: Immunoaffinity purified View All» Storage Conditions: 1 year at 4°C from date of shipment View All» UniProt Number: P35568 View All» Entrez Gene Number: NM_005544.1 View All» Gene Symbol:
  • IRS1

  • IRS-1

  • HIRS-1
    View All» Usage Statement:
    • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      View All» Key Applications:
      • Immunocytochemistry

      • Immunofluorescence
        View All» UniProt Summary: FUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).SIZE: 1242 amino acids; 131591 Da SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7.PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain. View All» Brand Family: Upstate View All» Product Name: Anti-IRS1 Antibody, Alexa Fluor® 555 conjugate | 16-258 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µg View All» Format: AlexaFluor®555 View All» Host: Rabbit View All»
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