货号：16-307

品牌：Merck Millipore

规格：

目录价：￥3978.00

市场价格：￥3381.30

会员价格：￥3182.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ZAP-70 (human) Antibody, clone 2F3.2, Alexa Fluor® 488 conjugate | 16-307 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes human ZAP-70. Does not recognize murine ZAP-70. View All» Molecular Weight: 70 kDa View All» Immunogen: GST-fusion protein containing the 2 tandem SH2 domains of human ZAP-70 corresponding to amino acids 1-254. Clone 2F3.2. View All» Isotype: IgG2 View All» Species Reactivity: Human View All» Control: Included Negative Control: Catalog # 16-240, Alexa Fluor® 488-conjugated Normal Mouse IgG. View All» Quality Assurance: Immunoblot Analysis: 2µg/ml of this lot detected ZAP-70 in RIPA lysates from human Jurkat cells. Immunocytochemistry: 2µg/ml of this lot showed positive immunostaining for ZAP-70 in Jurkat cells. Flow Cytometry: 0.2μg of this lot detected ZAP-70 in fixed and permeabilized Jurkat cells (see data). View All» Purification Method: Protein G purfied View All» Presentation: 125 µg of Alexa Fluor® 488-conjugated protein G purified mouse IgG2a in 250µl of PBS containing 1% BSA, 0.05% Tween®-20, 0.05% sodium azide. Liquid at 4°C. View All» Storage Conditions: 1 year at 4°C from date of shipment View All» UniProt Number: P43403 View All» Entrez Gene Number:

• NM_001079.3

• NM_207519.1
  View All» Gene Symbol:
  • ZAP70

  • ZAP-70

  • STD

  • TZK

  • SRK
    View All» Alternate Names: SRK, Syk-related Tyrosine Kinase, ZAP70 View All» Usage Statement:
    • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      View All» Key Applications:
      • Flow Cytometry

      • Immunocytochemistry

      • Immunofluorescence

      • Western Blotting
        View All» Entrez Gene Summary: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P43403 # Associates with the T-cell antigen receptor zeta chain (CD3Z). Plays a role in lymphocyte activation.SIZE: 619 amino acids; 69872 Da SUBUNIT: Interacts with SLA2 when it is phosphorylated. Interacts with CD3Z and with phosphorylated NFAM1. Interacts with CBLB (By similarity). Interacts with CBL and SLA when it is phosphorylated. The association with SLA (or SLA2) and CBL probably leads to its destruction. Interacts with SHB. Interacts with DEF6 (By similarity).TISSUE SPECIFICITY: Expressed in T- and natural killer cells.DOMAIN: SwissProt: P43403 The SH2 domain binds to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z.PTM: Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Tyr-319 phosphorylation is essential for full activity.DISEASE:SwissProt: P43403 # Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells.SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. & Contains 1 protein kinase domain. & Contains 2 SH2 domains. View All» Brand Family: Upstate View All» Product Name: Anti-ZAP-70 (human) Antibody, clone 2F3.2, Alexa Fluor® 488 conjugate | 16-307 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 125 µg View All» Format: Purified View All» Host: Mouse View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://www.16ao.com/thread-147328.htm
        © Merck Millipore代理16-307 Anti-ZAP-70 (human), clone 2F3.2, Alexa Fluor® 488 conjugate，产品报价联系微信jinshanbio