货号：16-321

品牌：Merck Millipore

规格：200UL

目录价：￥6754.00

市场价格：￥5740.90

会员价格：￥5403.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Ras Magnetic Bead Conjugate Antibody | 16-321 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes p21H-, K- and N-Ras. View All» Molecular Weight: 21 kDa View All» Immunogen: KLH-conjugated protein corresponding to human Ras. View All» Isotype: IgG2aκ View All» Background Information: The tumor oncoproteins HRas, KRas, and NRas are rated as Ras protoncogenes. Point mutations within Ras genes are frequently detected in human malignancies and in experimentally induced tumors in animals. View All» Species Reactivity:

• Human

• Rat

• Mouse
  View All» Species Reactivity Note: Proven to react with human, mouse and rat. Other species unknown. View All» Application Notes: Immunoprecipitation: 150 μg of this antibody has been reported to immunoprecipitate Ras. View All» Control: A431 whole cell lysate View All» Purification Method: Protein G purfied View All» Presentation: 20% slurry; 1xPBS, 0.05% sodium azide. Sufficient for 10 immunoprecipitation assays. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. DO NOT FREEZE View All» UniProt Number: P01116 View All» Entrez Gene Number: NP_203524 View All» Gene Symbol:
  • K-Ras

  • Ki-Ras

  • K-Ras2

  • Kras-2

  • p21B

  • KRAS

  • RASK2

  • HRAS

  • HA_RAS

  • N-RAS

  • H-RAS

  • NRAS

  • NRAS1

  • ALPS4
    View All» Alternate Names:
    • GTP- and GDP-binding peptide B

    • GTPase Hras

    • Ha-Ras1 proto-oncoprotein

    • Ras family small GTP binding protein H-Ras

    • Transforming protein p2

    • c-has/bas p21 protein

    • c-ras-Ki-2 activated oncogene

    • p19 H-RasIDX protein

    • transformation gene: oncogene HAMSV

    • v-Ha-ras Harvey rat sarcoma viral oncogene homolog
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» Entrez Gene Summary: Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.[supplied by OMIM] View All» UniProt Summary: FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.Enzyme regulation:Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).SIZE: 189 amino acids; 21,656 Da SUBUNIT: Interacts with PHLPP (By similarity).SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side.Involvement in disease: Defects in KRAS are a cause of acute myelogenous leukemia (AML) [MIM:601626]. AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development.Defects in KRAS are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. It is characterized by leukocytosis with tissue infiltration and in vitro hypersensitivity of myeloid progenitors to granulocyte-macrophage colony stimulating factor.Defects in KRAS are the cause of Noonan syndrome 3 (NS3) [MIM:609942]. Noonan syndrome (NS) [MIM:163950] is a disorder characterized by dysmorphic facial features, short stature, hypertelorism, cardiac anomalies, deafness, motor delay, and a bleeding diathesis. It is a genetically heterogeneous and relatively common syndrome, with an estimated incidence of 1 in 1000-2500 live births. Rarely, NS is associated with juvenile myelomonocytic leukemia (JMML). NS3 inheritance is autosomal dominant.Defects in KRAS are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant.KRAS mutations are involved in cancer development. View All» Product Name: Anti-Ras Magnetic Bead Conjugate Antibody | 16-321 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Purified View All» Host: Mouse View All»
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