R&D Systems代理BAF4128 Human CEACAM-5 Biotinylated Affinity Purified PAb (50 UG)-试剂-金山科研平台

R&D Systems代理BAF4128 Human CEACAM-5 Biotinylated Affinity Purified PAb (50 UG)

2025-06-27

货号：BAF4128

品牌：R&D Systems

规格：50 UG

目录价：￥5070.00

市场价格：￥4056.00

会员价格：￥4056.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: CEACAM-5/CD66e Long Name: Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 Aliases: CD66e; CEA Entrez Gene IDs: 1048 (Human) Background: CEACAM-5

View CEACAM-5 IHC images. CEACAM-5, also known as CEA and CD66e, belongs to the large family of CEACAM and pregnancy specific glycoproteins. CEACAM molecules are either transmembrane or GPI-linked, and are differentially expressed between species. Orthologs of human CEACAM-5 have not been described in other species. CEACAM-5, which is expressed primarily by epithelial cells, consists of an N-terminal Ig like V-set domain followed by six Ig-like C2-set domains and a GPI anchor. CEACAM-5 is synthesized as a 180 kDa, variably glycosylated molecule of which approximately 60% is carbohydrate. CEACAM-5 functions as a calcium independent adhesion molecule through homophilic and heterophilic interactions with CEACAM-1.

CEACAM-5 is restricted to the apical face of intestinal epithelial cells in the adult but is more diffuse during embryonic development and in tumors. This is consistent with a role in the development and maintenance of epithelial architecture. CEACAM-5 is upregulated in a wide variety of human tumors and is a commonly used cancer marker. It promotes tumor cell migration, invasion, adhesion, and metastasis. CEACAM-5 also contributes to tumor formation by maintaining cellular proliferation in the presence of differentiation stimuli, and by blocking apoptosis following loss of ECM anchorage (anoikis).

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