货号：17-366

品牌：Merck Millipore

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目录价：￥10378.00

市场价格：￥8821.30

会员价格：￥8302.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: TOPglow/FOPglow TCF Reporter Kit View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 1 kit View All» Product Overview: TOPglow (TCF reporter plasmid): Transfection grade T cell factor (TCF) reporter plasmid containing four copies of the Tcf binding site (wt) upstream of E1B TATA box and Luciferase open reading frame. FOPglow (mutant TCF binding sites): Transfection grade T cell factor (TCF) reporter plasmid containing three copies of the TCF binding site (mutated) upstream of E1B TATA box and Luciferase open reading frame. This plasmid serves as a negative control to TOPglow which contains wild type TCF binding sites. View All» Key Applications: Transfection View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes transcription factor 4, a basic helix-turn-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Multiple alternatively spliced transcript variants that encode different proteins have been described. View All» UniProt Summary: FUNCTION: SwissProt: P20823 # Required for the expression of several liver specific genes. Binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.SIZE: 631 amino acids; 67356 Da SUBUNIT: Binds DNA as a dimer.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Liver.DISEASE: SwissProt: P20823 # Defects in HNF1A may predispose to hepatic adenomas [MIM:142330]. Hepatic adenomas are benign tumors at risk of malignant transformation. Bi-allelic inactivation of HNF1A, whether sporadic or associated with MODY3, may be an early step in the developmant of some hepatocellular carcinomas. & Defects in HNF1A are the cause of maturity onset diabetes of the young type 3 (MODY3) [MIM:600496]; also symbolized MODY-3. MODY [MIM:606391] is a form of diabetes characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion. The clinical phenotype of MODY3 is characterized by severe insulin secretory defects, and by major hyperglycemia associated with microvascular complications. & Defects in HNF1A are a cause of susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100].SIMILARITY: SwissProt: P20823 ## Belongs to the HNF1 homeobox family. & Contains 1 homeobox DNA-binding domain. View All» Brand Family: Upstate View All» Gene Symbol:

• TCF1

• MODY3

• HNF1

• HNF-1A

• TCF-1

• HNF1A

• LFB1

• HNF1a
  View All» Product Name: TOPglow/FOPglow TCF Reporter Kit View All» Quality Assurance: Routinely evaluated by diagnostic DNA digest. TOPglow and FOPglow plasmids were cut with HindllI, which generated the expected fragment of approximately 5.2kb. View All» Components:
  • TOPglow (TCF reporter plasmid) (Cat.# 21-204)

  • FOPglow (mutant TCF binding sites) (Cat.# 21-205)
    View All» UniProt Number:
    • P20823

    • P15923

    • P15884
      View All» Entrez Gene Number: NM_000545.4 View All»
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