货号：17-439

品牌：Merck Millipore

规格：20assays

目录价：￥12178.00

市场价格：￥10351.30

会员价格：￥9742.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: RalB Activation Assay Kit (non-radioactive) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 20 assays View All» Key Applications: G-Protein Assay View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» UniProt Summary: FUNCTION: SwissProt: Q15311 # Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDC2 to switch off endocytosis, One of its substrates would be EPN1/Epsin.SIZE: 655 amino acids; 76063 Da SUBUNIT: Interacts with the GTP-bound form of RALA, RALB, CDC42 and RAC1. Interacts with REPS1 and REPS2 and this does not affect the Ral-binding activity. Interacts with DAB2IP. Interacts with catalytically active CCNB1 and CDC2 during mitosis. Interacts with EPN1, NUMB and TFAP2A during interphase and mitosis.SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.TISSUE SPECIFICITY: Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes.SIMILARITY: SwissProt: Q15311 ## Contains 1 Rho-GAP domain. View All» Brand Family: Upstate View All» Storage Conditions: 1 year at -20°C from date of shipment View All» Gene Symbol:
  • RALBP1

  • RLIP1

  • RIP1

  • RalBP1

  • RIP

  • RLIP76
    View All» Product Name: RalB Activation Assay Kit (non-radioactive) View All» Alternate Names: RAS-like protein B; v-ral simian leukemia viral oncogene homolog B; GTP binding protein View All» Materials Required but Not Delivered: Stimulated and Non-stimulated Cell Lysates Pipettes, Micropipettes and Tips Electrophoresis and Immunoblotting Equipment Microcentrifuge Microcentrifuge Tubes Ral Activators Tissue Culture Supplies 4C Tube Rocker Glycerol aprotinin PMSF Anti-Mouse Secondary Antibody and Detection Reagents TRIS Buffered Saline (TBS), Ice Cold View All» Quality Assurance: Routinely evaluated by non-radioactive Kinase Assay. View All» Components:
    • anti-RalB, clone 25 (Cat.# 04-037)

    • Ral Assay Reagent (Ral BP1, agarose) (Cat.# 14-415)

    • Mg2+ Lysis/Wash Buffer, 5X (Cat.# 20-168)

    • 100X GTPγS, 10mM (Cat.# 20-176)

    • 100X GDP, 100mM (Cat.# 20-177)
      View All» UniProt Number: Q15311 View All» Entrez Gene Number: NM_006788.3 View All»
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