金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: IL-10 R alpha Long Name: Interleukin 10 Receptor alpha Aliases: CDw210a; CD210a; IL10RA Entrez Gene IDs: 3587 (Human); 16154 (Mouse) Background: IL-10 R alpha

Human and mouse IL-10 receptors are structurally related to the IFN-gamma receptor. These receptors are members of the class II subgroup of the cytokine receptor superfamily. The deduced amino acid sequence of human IL-10 R is approximately 60% identical to mouse IL-10 R. Although human IL-10 has cross-species activities and is active on mouse cells, mouse IL-10 is species-specific in its actions and does not bind to the human IL-10 receptor. The human IL-10 R gene has been mapped to chromosome 11q23.3. Recombinant IL-10 soluble receptor, consisting of the extracellular domain of IL-10 R, binds IL-10 with high affinity in solution and is a potent IL-10 antagonist.