货号：19-134

品牌：Merck Millipore

规格：1mg

目录价：￥3305.00

市场价格：￥2809.25

会员价格：￥2644.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: p38/SAPK2 Inhibitor (SB 202190) View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 1 mg View All» Key Applications: Kinase Assay View All» Application Notes: Potent inhibitor of p38 alpha/SAPK2a and p38 beta/SAPK2b kinases. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase. View All» UniProt Summary: FUNCTION: SwissProt: Q15759 # Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.COFACTOR: Magnesium (By similarity).SIZE: 364 amino acids; 41357 Da TISSUE SPECIFICITY: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.DOMAIN:SwissProt: Q15759 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme (Probable).SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Protein Target: p38/SAPK2 View All» Presentation: C₂0H₁₄FN₃O View All» Storage Conditions: 3 years at -20°C View All» Target Sub-Family: CMGC View All» Gene Symbol:

• MAPK11

• p38-2

• p38b

• P38B

• p38Beta

• p38beta2

• SAPK2B

• SAPK2

• PRKM11

• P38BETA2
  View All» Product Name: p38/SAPK2 Inhibitor (SB 202190) View All» Quality Assurance: Routinely evaluated in a kinase assay as an inhibitor. View All» UniProt Number: Q15759 View All» Entrez Gene Number: NM_002751.5 View All»
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