货号：20-132

品牌：Merck Millipore

规格：1mL

目录价：￥2144.00

市场价格：￥1822.40

会员价格：￥1715.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PKA/CaMK Inhibitor Cocktail View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 1 mL View All» Key Applications: Kinase Assay View All» Application Notes: For use in kinase assays. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. View All» UniProt Summary: FUNCTION: SwissProt: P17612 # Phosphorylates a large number of substrates in the cytoplasm and the nucleus.SIZE: 351 amino acids; 40590 Da SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).TISSUE SPECIFICITY: Isoform 2 is sperm specific.PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).SIMILARITY: SwissProt: P17612 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Presentation: 20mM MOPS, pH 7.2, 25mM β-glycerophosphate, 1mM sodium orthovanadate, 1mM dithiothreitol, 1mM CaCl2 View All» Storage Conditions: 1 year at -20°C View All» Gene Symbol:

• PRKACA

• MGC102831

• PKACA

• MGC48865
  View All» Product Name: PKA/CaMK Inhibitor Cocktail View All» UniProt Number: P17612 View All» Entrez Gene Number:
  • NM_002730.3

  • NM_207518.1
    View All»
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