货号：23-028

品牌：Merck Millipore

规格：10Ug

目录价：￥7696.00

市场价格：￥6541.60

会员价格：￥6156.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: IkBa, activated View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Background Information: IκBα is a cellular protein that inhibits the transcription factor NF-κB. NF-κB plays a central role in cellular stress and inflammatory responses by controlling cytokine-inducible gene expression and lymphocyte stimulation by antigens. In non-stimulated cells NF-κB is sequestered in the cytoplasm via the inhibitory protein IκBα, which obscures the nuclear localization signal of NF-κB and also blocks its ability to bind DNA. In response to various stimuli, including viral infection, ultraviolet radiation and inflammatory cytokines, IκBα is phosphorylated by the protein kinase complex IKK, which triggers its rapid degradation by ubiquitin mediated proteolysis. The liberated NF-κB then translocates to the nucleus and activates the expression of target genes. Mutations in the gene for IκBα result in the functional impairment of NF-κB which causes a decreased production of proinflammatory cytokines and certain interferons, rendering patients susceptible to infection. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: Substrate View All» Brand Family: Upstate View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Long Description: N-terminal c-Myc, 6His-tagged, recombinant human IκBα full length, expressed by baculovirus in Sf21 insect cells. Purified using immobilized metal affinity chromatography. Phosphorylated in vitro using IKKα, active (Item # 14-461) View All» Product Name: IkBa, activated View All» Entrez Gene Number: M69043 (GenBank Number) View All» Alternate Names:

• NF-kappa-B inhibitor alpha

• I-kappa-B-alpha

• Major histocompatibility complex enhancer-binding protein MAD3
  View All» Purification Method: Purified using immobilized metal affinity chromatography. View All»
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