货号：23-041

品牌：Merck Millipore

规格：10Ug

目录价：￥7531.00

市场价格：￥6401.35

会员价格：￥6024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: c-Cbl, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Background Information: Intracellular signals mediated by receptor tyrosine kinases play a pivotal role in morphogenesis, cell fate determination and pathogenesis. c-Cbl is a ubiquitin ligase (E3) that facilitates the regulation of these pathways, attenuating signalling through ubiquitination and subsequent protein degradation. c-Cbl contains several functional domains, including a tyrosine kinase-binding domain that associates with a number of protein tyrosine kinases in a phosphorylation-dependent manner, a catalytic RING-finger domain that interacts with E2s and is essential for E3 activity and a C-terminal proline rich domain which mediates interactions with SH3 containing proteins. Mutations in the gene for c-Cbl have been implicated in a number of human cancers, particularly acute myeloid leukaemia. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: E3 View All» Brand Family: Upstate View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Long Description: N-terminal GST-tagged, recombinant human c-Cbl full length, expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose. View All» Product Name: c-Cbl, active View All» Entrez Gene Number: NM_005188 (GenBank Number) View All» Alternate Names:

• E3 ubiquitin-protein ligase CBL

• Casitas B-lineage lymphoma proto-oncogene

• RING finger protein 55

• Signal transduction protein CBL

• CBL2

• RNF55
  View All» Purification Method: Purified using glutathione sepharose. View All»
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