货号：23-043-K

品牌：Merck Millipore

规格：

目录价：￥410.00

市场价格：￥348.50

会员价格：￥328.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Kit View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: BULK View All» Background Information: Kit belongs to the family of type III receptor tyrosine kinases. It mediates the cellular response to stem cell factor and plays a major role in survival, expansion and differentiation of haematopoietic progenitor cells and reproductive stem cells. The activation of Kit is tightly regulated and uncontrolled Kit activity contributes to the growth of diverse human tumours. Gain-of-function mutations have been described in a number of malignancies, including acute myeloid leukaemia, small cell lung cancer, gastrointestinal stromal tumours and testicular cancer. Negative regulation of Kit signalling has been shown to occur mainly through ubiquitin-mediated internalization and degradation of the receptor. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: Substrate View All» Brand Family: Upstate View All» Product Name: Kit View All» Alternate Names:

• Mast/stem cell growth factor receptor

• Proto-oncogene c-Kit

• Tyrosine-protein kinase Kit

• CD_antigen=CD117
  View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Long Description: N-terminal c-Myc, GST-tagged, recombinant human Kit amino acids 544-end, expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose. View All» Entrez Gene Number: X06182 (GenBank Number) View All» Purification Method: Purified using glutathione sepharose. View All»
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