货号：23-045-K

品牌：Merck Millipore

规格：

目录价：￥410.00

市场价格：￥348.50

会员价格：￥328.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: HIF-1α View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: BULK View All» Background Information: HIF-1α is the oxygen sensitive subunit of the hypoxia inducible factor HIF-1 which is an essential mediator of the cellular oxygen-signalling pathway. Under hypoxic conditions HIF-1α activates the transcription of over 40 genes, including those that control glucose uptake, metabolism, angiogenesis, erythropoiesis, cell proliferation, and apoptosis. The expression of HIF-1α is commonly increased in a variety of human tumours, and correlates with poor patient prognosis. Under normoxia this protein interacts with the ubiquitin ligase VHL complex, leading to its polyubiquitination and subsequent proteasomal degradation. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: Substrate View All» Brand Family: Upstate View All» Product Name: HIF-1α View All» Alternate Names:

• Hypoxia-inducible factor 1-alpha

• ARNT-interacting protein

• Basic-helix-loop-helix-PAS protein MOP1

• bHLHe78

• PAS domain-containing protein 8
  View All» Specific Activity: For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. View All» Long Description: N-terminal c-Myc, GST-tagged, recombinant human HIF-1α amino acids 331-609, expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose. View All» Entrez Gene Number: NM_001530 (GenBank Number) View All» Purification Method: Purified using glutathione sepharose. View All»
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