货号：23-047-K

品牌：Merck Millipore

规格：

目录价：￥410.00

市场价格：￥348.50

会员价格：￥328.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: UbcH7, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: BULK View All» Background Information: Ubiquitin-conjugating (E2) enzymes are characterized by the presence of a highly conserved ubiquitin-conjugating domain which accommodates ATP-activated ubiquitin (Ub) via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the ubiquitin-activating E1 enzyme and ubiquitin ligase E3 enzymes and are able to differentiate effects on downstream substrates, either with a single Ub molecule or a Ub chain. While E3s are involved in substrate selection, E2s are the main determinants for selection of the lysine to construct Ub chains, which thereby directly control the cellular fate of the substrate.UbcH7 shows broad specificity for HECT-type E3s but does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine. Despite lacking this lysine reactivity, UbcH7 exhibits activity with the RBR family E3 enzymes, such as Parkin and ARIH1. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: E2 View All» Brand Family: Upstate View All» Long Description: N-terminal HA, 6His-tagged, recombinant human UbcH7 full length, expressed in E.coli. View All» Product Name: UbcH7, active View All» Entrez Gene Number: GenBank X92962 View All» Alternate Names:

• Ubiquitin-conjugating enzyme E2 L3

• L-UBC

• Ubiquitin carrier protein L3

• Ubiquitin-conjugating enzyme E2-F1

• Ubiquitin-protein ligase L3

• UBE2L3

• UBCE7
  View All» Purification Method: Purified using immobilized metal affinity chromatography. View All»
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