货号：23-048

品牌：Merck Millipore

规格：10Ug

目录价：￥7800.00

市场价格：￥6630.00

会员价格：￥6240.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Parkin, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Background Information: Parkin is an E3-ubiquitin ligase belonging to the RBR (RING – In Between RING – RING) family. Mutations in Parkin that result in a loss-of-function are the most frequent cause of familial Parkinson’s disease and are responsible for a large percentage of autosomal recessive juvenile parkinsonism (AR-JP). In addition to its auto-ubiquitination, Parkin can also ubiquitinate various substrates, including the CDK2-interacting protein cyclin E1, the a-synuclein-interacting protein synphilin-1, the synaptic vesicle-associated CDC-rel1 and the p38 subunit of aminoacyl-tRNA synthetase/JTV-1. Ubiquitination of substrates occurs in conjunction with the E2 enzymes UbcH7, UbcH8 or UbcH13/Uev1. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: E3 View All» Brand Family: Upstate View All» Long Description: N-terminal 6His-tagged, recombinant human Parkin full length, expressed by baculovirus in Sf21 insect cells. Purified using immobilized metal affinity chromatography. View All» Product Name: Parkin, active View All» Entrez Gene Number: GenBank NM_004562 View All» Alternate Names:

• Parkinson juvenile disease protein 2

• PARK2

• PRKN
  View All» Purification Method: Purified using immobilized metal affinity chromatography. View All»
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