货号：23-049

品牌：Merck Millipore

规格：

目录价：￥6685.00

市场价格：￥5682.25

会员价格：￥5348.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: p38/JTV-1 View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10 µg View All» Background Information: p38/JTV-1 is a scaffold required for the assembly and stability of the multi-tRNA synthetase complex, an essential enzyme that ligates specific amino acids to tRNAs before protein synthesis. It plays a pivotal role in the control of cell proliferation and has been shown to interact with FUSE binding protein, stimulating its ubquitination and degradation and leading to the down-regulation of the transcription factor c-Myc which is required for differentiation of functional alveolar type II cells. Genetic disruption of p38/JTV-1 in mice has been observed to cause neonatal lethality.p38/JTV-1 is ubiquitinated by the E3 ligase Parkin, leading to its proteosomal degradation. It has been shown to accumulate in Parkin-deficient mice and in the brain tissue of patients with hereditary Parkinson’s, suggesting that it may play a role in the pathogenicity of this disease. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: Substrate View All» Brand Family: Upstate View All» Long Description: N-terminal cMyc, GST-tagged, recombinant human p38/JTV-1 full length, expressed by baculovirus in Sf21 insect cells. Purified using immobilized metal affinity chromatography. View All» Product Name: p38/JTV-1 View All» Entrez Gene Number: GenBank BC002853 View All» Alternate Names:

• Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

• AIMP2

• Multisynthase complex auxiliary component p38
  View All» Purification Method: Purified using immobilized metal affinity chromatography. View All»
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