货号：23-050M

品牌：Merck Millipore

规格：

目录价：￥38063.00

市场价格：￥32353.55

会员价格：￥30450.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: CHIP, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Background Information: CHIP is an E3 ubiquitin-protein ligase which targets misfolded chaperone substrates for proteasomal degradation. It contains multiple domains, including a tetratricopeptide repeat (TPR) domain that allows interaction with molecular chaperones, such as Hsp70 and Hsp90 and a U-box domain that confers its E3 ubiquitin ligase function. It has been demonstrated that CHIP preferentially ubiquitinates chaperone-bound substrates, of which there are a diverse range including CFTR, ErbB2 and LRRK2, but also targets Hsp70 itself to the proteasome for degradation when misfolded substrates are not present. This sequential degradation of misfolded substrate and chaperone provides a homeostatic mechanism for regulating chaperone levels to reflect the status of protein folding within the cytoplasm. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: E3 View All» Brand Family: Upstate View All» Long Description: N-terminal 6His-tagged, recombinant human CHIP full length, expressed in E.coli. Purified using immobilized metal affinity chromatography. View All» Product Name: CHIP, active View All» Entrez Gene Number: GenBank NM_005861 View All» Alternate Names:

• Carboxy terminus of Hsp70-interacting protein

• CLL-associated antigen KW-8

• Antigen NY-CO-7

• STIP1 homology and U box-containing protein 1

• STUB1
  View All» Purification Method: Purified using immobilized metal affinity chromatography. View All»
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