货号：23-051M

品牌：Merck Millipore

规格：

目录价：￥9940.00

市场价格：￥8449.00

会员价格：￥7952.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: UbcH13/Uev1A, active View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 250 µg View All» Background Information: Ubiquitin-conjugating (E2) enzymes are characterized by the presence of a highly conserved ubiquitin-conjugating domain which accommodates ATP-activated ubiquitin (Ub) via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the ubiquitin-activating E1 enzyme and ubiquitin ligase E3 enzymes and are able to differentiate effects on downstream substrates, either with a single Ub molecule or a Ub chain. While E3s are involved in substrate selection, E2s are the main determinants for selection of the lysine to construct Ub chains, which thereby directly control the cellular fate of the substrate. Typically, a polyubiquitin chain that targets a protein for degradation by the proteasome is linked through lysine-48 (K48) of ubiquitin, however ubiquitin chains linked through other lysines such as K63 have also been found. K63 linked chains are non-degradative and play a role in signalling and protein trafficking. The heterodimeric E2 complex of Ubc13 and Uev1A has been shown to be involved in the formation of K63 linkages in conjunction with a number of E3 ligases including Parkin, CHIP and TRAF6. View All» Key Applications: Enzyme Assay View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Species: Human View All» Cascade Component: E2 View All» Brand Family: Upstate View All» Long Description: Complex of N-terminal HA, 6His-tagged, recombinant human UbcH13 full length and untagged recombinant human Uev1A full length, expressed in E.coli. Purified using immobilized metal affinity chromatography. View All» Product Name: UbcH13/Uev1A, active View All» Entrez Gene Number: GenBank NM_003348 (UbcH13)GenBank NM_001032288 (Uev1A) View All» Alternate Names:

• UbcH13 - Ubiquitin-conjugating enzyme E2 N

• Bendless-like ubiquitin-conjugating enzyme

• Ubiquitin carrier protein N

• UBE2N

• Ubc13

• Uev1A - Ubiquitin-conjugating enzyme E2 variant 1

• CROC-1

• UBE2V1
  View All» Purification Method: Purified using immobilized metal affinity chromatography. View All»
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