金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: IL-3 R alpha/CD123 Long Name: Interleukin 3 Receptor alpha Aliases: CD123; IL3RA Entrez Gene IDs: 3563 (Human); 16188 (Mouse) Background: IL-3 R alpha

IL-3 R alpha binds IL-3 with relatively low affinity. In the presence of IL-3 R beta, however, IL-3 R alpha has a much higher affinity for IL-3. It is not clear how signal transduction occurs following IL-3 binding. The IL-3 R alpha chain has a very short intracellular domain while the IL-3 R beta chain has a very large cytoplasmic domain. Recent studies suggest that formation of IL-3 R beta-beta homodimers initiates signaling events. The IL-3 R beta chain is also shared by the receptors for IL-5 and GM-CSF. Cells known to express IL-3 receptors include hematopoietic progenitors, epithelial cells, double negative T cells, mast cells, basophils and blood monocytes.