金山科研平台，产品价格货期咨询微信：jinshanbio Molecule Information: Common beta Chain Aliases: CD131; CSF2RB; GM-CSF R beta; IL-3 R beta; IL-5 R beta Entrez Gene IDs: 1439 (Human); 12983 (Mouse) Background: Common beta Chain The high-affinity receptors for Interleukin-3 (IL-3), IL-5, and Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) consist of a cytokine-specific a chain, and a shared common beta chain subunit (CD131) that is essential for receptor signaling. CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective heteroreceptor complex. Phosphorylation of CD131 following receptor activation imparts growth and survival signals to the responding hematopoietic cells.