货号：33-047

品牌：Merck Millipore

规格：10000wells

目录价：￥217396.00

市场价格：￥184786.60

会员价格：￥173916.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: PI 3-Kinase 3-step HTRF™ Assay View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 10,000 wells View All» Key Applications: Kinase Assay View All» Species Reactivity:

• Human

• Mouse
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. View All» UniProt Summary: FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.SIZE: 1068 amino acids; 124284 Da SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain. View All» Brand Family: Upstate View All» Storage Conditions: 12 months at -70°C View All» Target Sub-Family: PI3K/PI4K View All» Gene Symbol:
  • PIK3CA

  • MGC142163

  • PI3K

  • MGC142161

  • p110-alpha
    View All» Product Name: PI 3-Kinase 3-step HTRF™ Assay View All» Analytes Available: PI 3-Kinase View All» Components:
    • 4X Reaction Buffer

    • PIP2 (substrate, 1mM stock)

    • DM A Reaction Buffer

    • DM B Reaction Buffer

    • DM C Reaction Buffer

    • BPIP3

    • Stop Reagent
      View All» UniProt Number: P42336 View All» Detection Methods: HTRF View All» Packaging: Kit capacity: 10,000 wells View All» Entrez Gene Number: NM_006218.2 View All»
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