货号：36-005

品牌：Merck Millipore

规格：

目录价：￥4271.00

市场价格：￥3630.35

会员价格：￥3416.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Bim EL (Ser55) Antibody | 36-005 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Bim EL phosphorylated on serine 55. View All» Molecular Weight: 48 kDa View All» Immunogen: Peptide corresponding to amino acids 55-63 of human phospho-Bim EL (Ser55). View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot on phosphorylated Bim-GST. View All» Purification Method: Protein A chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%. View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: O43521 View All» Entrez Gene Number:

• NM_138622.2

• NM_138623.2

• NM_138624.2

• NM_138626.2

• NM_138627.2

• NM_207003.1

• NM_006538.3

• NM_138621.3

• NM_207002.2
  View All» Gene Symbol:
  • BCL2L11

  • BimL

  • BIM

  • BIM-beta7

  • BOD

  • BAM

  • BimEL

  • BIM-beta6

  • BIM-alpha6
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. View All» UniProt Summary: FUNCTION: SwissProt: O43521 # Induces apoptosis. Isoform BimL is more potent than isoform BimEL.SIZE: 198 amino acids; 22171 Da SUBUNIT: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including Mcl-1, Bcl-2, Bcl-X(L), BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK (By similarity).SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Note=Associated with intracytoplasmic membranes (By similarity).DOMAIN: SwissProt: O43521 The BH3 motif is required for Bcl-2 binding and cytotoxicity. SIMILARITY: View All» Brand Family: Upstate View All» Product Name: Anti-phospho-Bim EL (Ser55) Antibody | 36-005 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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