货号：36-011

品牌：Merck Millipore

规格：200UL

目录价：￥6626.00

市场价格：￥5632.10

会员价格：￥5300.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-nitro-α/β-Synuclein Antibody, clone nSyn12 | 36-011 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: α-Synuclein nitrated at Tyr125 and Tyr136β-Synuclein nitrated at Tyr130 View All» Molecular Weight: α-Synuclein, Mr 14.5kDaβ-Synuclein, Mr 17kDa View All» Immunogen: full-length recombinant human α-Synuclein nitrated in vitro View All» Modifications: Nitration View All» Species Reactivity: Human View All» Quality Assurance: rountinely evaluated on recombinant protein nitrated in vitro View All» Purification Method: Ascites View All» Presentation: ascites with 0.05% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number:

• P37840

• Q16143
  View All» Entrez Gene Number:
  • NM_000345.2

  • NM_007308.1
    View All» Gene Symbol:
    • SNCA

    • MGC110988

    • PD1

    • alpha-synuclein

    • NACP

    • PARK1

    • PARK4

    • Alpha-synuclein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q16143 # Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.SIZE: 134 amino acids; 14288 Da SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Expressed predominantly in brain; concentrated in presynaptic nerve terminals.PTM: Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.DISEASE: SwissProt: Q16143 # Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.SIMILARITY: SwissProt: Q16143 ## Belongs to the synuclein family. View All» Brand Family: Upstate View All» Product Name: Anti-nitro-α/β-Synuclein Antibody, clone nSyn12 | 36-011 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Purified View All» Host: Mouse View All»
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