金山科研平台，产品价格货期咨询微信：jinshanbio Assay Type:Solid Phase Sandwich ELISA Format:96-well strip plate Assay Length:4.5 hours Sample Type & Volume Required Per Well:Cell Culture Supernates (50 µL), Serum (10 µL), Heparin Plasma (10 µL), Urine (50 µL), Human Milk (50 µL) Sensitivity:0.157 ng/mL Assay Range:0.781 - 50 ng/mL (Serum, Heparin Plasma, Cell Culture Supernates, Human Milk, Urine) Specificity:Natural and recombinant human ENPP-2 Cross-reactivity: Interference:No significant interference observed with available related molecules. Molecule Information: ENPP-2/Autotaxin Long Name: Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 Aliases: ATX; Autotaxin; Lysophosphatidic Acid; NPP2; PDNP2 Entrez Gene IDs: 5168 (Human); 18606 (Mouse); 84050 (Rat) Background: ENPP-2 ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain. Unlike ENPP-1 and ENPP-3, ENPP-2 has weak activity against nucleotides, but exhibits a lysophospholipase D activity which allows the formation of lysophosphatidic acid (LPA) and choline from lysophosphatidylcholine. The hydrolysis of nucleotides and lysophospholipids by ENPP-2 is mediated by a single catalytic site. Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung.