金山科研平台，产品价格货期咨询微信：jinshanbio Assay Type:Solid Phase Sandwich ELISA Format:96-well strip plate Assay Length:4.5 hours Sample Type & Volume Required Per Well:Cell Culture Supernates (50 µL), Serum (13 µL), EDTA Plasma (25 µL), Platelet-poor EDTA Plasma (100 µL), Heparin Plasma (25 µL), Platelet-poor Heparin Plasma (100 µL) Sensitivity:15.6 pg/mL Assay Range:31.2 - 2,000 pg/mL (Serum, Heparin Plasma, Cell Culture Supernates, EDTA Plasma, Platelet-poor EDTA Plasma, Platelet-poor Heparin Plasma) Specificity:Oligomeric forms of natural and recombinant human Dkk-1 Cross-reactivity: Interference:No significant interference observed with available related molecules. Molecule Information: Dkk-1 Long Name: Dickkopf-1 Entrez Gene IDs: 22943 (Human); 13380 (Mouse) Background: Dkk Family Members of the dickkopf-related protein family (Dkk-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. Dkk-3 and -4 also have one prokineticin domain. Dkk-1, -2, and -4 function as antagonists of canonical Wnt signaling by binding to LRP5/6, preventing interaction of LRP5/6 with Wnt-Frizzled complexes. Dkk-1, -2, and -4 also bind cell surface Kremen-1 or -2 and promote the internalization of LRP5/6. Antagonistic activity of Dkk-3 has not been demonstrated. Dkk proteins have distinct patterns of expression in adult and embryonic tissues and have a wide range of effects on tissue development and morphogenesis. The Dkk family also includes Soggy, which is homologous to Dkk-3 but not to the other family members. Soggy has not been shown to inhibit Wnt signaling, and its role in the pathway is unclear.