金山科研平台，产品价格货期咨询微信：jinshanbio Format:96-well strip plate Assay Length:4.5 hours Sample Type & Volume Required Per Well:Cell Culture Supernates (50 µL), Serum (50 µL), EDTA Plasma (50 µL), Heparin Plasma (50 µL), Human Milk (10 µL) Sensitivity:10 pg/mL Assay Range:78.1 - 5,000 pg/mL (Serum, Heparin Plasma, Cell Culture Supernates, Human Milk, EDTA Plasma) Specificity:Natural and recombinant human TIMP-4. This kit detects recombinant human TIMP-4 in both free and MMP-bound forms. Cross-reactivity: Interference:No significant interference observed with available related molecules. Molecule Information: TIMP-4 Long Name: Tissue Inhibitors of Metalloproteinases 4 Entrez Gene IDs: 7079 (Human); 110595 (Mouse) Background: TIMPs TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.