R&D Systems代理DY1126 Mouse Neprilysin DuoSet ELISA, 15 Plate (1 KT)-试剂-金山科研平台

R&D Systems代理DY1126 Mouse Neprilysin DuoSet ELISA, 15 Plate (1 KT)

2025-06-27

货号：DY1126

品牌：R&D Systems

规格：1KT

目录价：￥9280.00

市场价格：￥7424.00

会员价格：￥7424.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Assay Type:ELISA Development Kit Assay Length:4 hours 40 minutes (after plate preparation) Sample Type & Volume Required:100 µL Sufficient Materials:For fifteen 96-well plates* Range:93.8 - 6,000 pg/mL Specificity:Please see the product datasheet Molecule Information: Neprilysin/CD10 Aliases: CALLA; CD10; Enkephalinase; Leu-19; MME; Neutral Endopeptidase 24.11; NKH1 Entrez Gene IDs: 4311 (Human); 17380 (Mouse); 24590 (Rat) Background: Neprilysin (CD10)

View Neprilysin IHC images.The neprilysin (NEP) family of zinc metallopeptidases includes neprilysin, endothelin-converting enzyme-2 (ECE-2), PEX, damage induced neuronal endopeptidase (DINE), Kell and several neprilysin-like proteins. Neprilysin is expressed at the cell surface of a variety of cell types. Enzymatically, neprilysin functions both as an endopeptidase with a thermolysin-like specificity and as a dipeptidylcarboxypeptidase. Neprilysin has been shown to be involved in the degradation of enkephalins in the mammalian brain and the inactivation of circulating atrial natriuretic peptide. Neprilysin has also been identified as the common acute lymphoblastic leukemia antigen (CALLA), and to be expressed on the surface of lymphocytes in some disease states. These and other observations have resulted in considerable clinical interest in neprilysin as a potential target for analgesics and antihypertensive drugs. Neprilysin is also a major degrading enzyme of amyloid-beta peptide (A-beta) in the brain, indicating that down-regulation of neprilysin activity, which could be caused by aging, can contribute to the development of Alzheimer's disease by promoting A-beta accumulation.

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