货号：46-604

品牌：Merck Millipore

规格：EA

目录价：￥3253.00

市场价格：￥2765.05

会员价格：￥2602.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MILLIPLEX MAP Active Caspase 3 MAPmate View All» Trade Name: MILLIPLEX View All» Qty/Pk: 1 kit View All» Key Applications: Multiplexing View All» Application Notes: The MILLIPLEX MAP Active Caspase 3 MAPmates pair is used in conjunction with the MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog # 48-602) to detect the presence of active Caspase 3 in cell lysates using the Luminex® 100 IS, 200, or HTS system View All» Species Reactivity: Human View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. View All» UniProt Summary: FUNCTION: SwissProt: P42574 # Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.SIZE: 277 amino acids; 31608 Da SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 17 kDa (p17) and a 12 kDa (p12) subunit.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.PTM: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.SIMILARITY: SwissProt: P42574 ## Belongs to the peptidase C14 family. View All» Brand Family: Upstate View All» Gene Symbol:

• CASP3

• apopain

• procaspase3

• CPP-32

• Apopain

• Yama

• CASP-3

• CPP32B

• SCA-1

• CPP32
  View All» Product Name: MILLIPLEX MAP Active Caspase 3 MAPmate View All» Analytes Available: Caspase 3, Caspase 3 (Active) View All» Configuration: Single Plex View All» Components:
  • Anti-Caspase 3 Beads

  • Anti-Active Caspase 3, Biotin
    View All» UniProt Number: P42574 View All» Panel Type: Cell Signaling View All» Detection Methods:
    • Fluorescent

    • Luminex xMAP
      View All» Packaging: 100 assay points View All» Entrez Gene Number:
      • NM_004346.3

      • NM_032991.2
        View All»
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