货号：46-632

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MILLIPLEX MAP Total CREB MAPmate View All» Trade Name: MILLIPLEX View All» Qty/Pk: 1 kit View All» Key Applications: Multiplexing View All» Application Notes: The MILLIPLEX MAP Total CREB MAPmates pair is used in conjunction with the MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog # 48-602) to detect the presence of total CREB in cell lysates using the Luminex® 100 IS, 200, or HTS system. View All» Species Reactivity: Human View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms. View All» UniProt Summary: FUNCTION: SwissProt: P16220 # This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE.SIZE: 341 amino acids; 36688 Da SUBUNIT: Binds DNA as a dimer. Interacts PPRC1 and with HTLV-1 Tax-1.SUBCELLULAR LOCATION: Nucleus.PTM: Stimulated by phosphorylation. Phosphorylation of both Ser- 133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP and EP300 binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: P16220 ## Belongs to the bZIP family. & Contains 1 bZIP domain. & Contains 1 KID (kinase-inducible) domain. View All» Brand Family: Upstate View All» Storage Conditions: 1 year at 4°C View All» Gene Symbol:

• CREB1

• MGC9284

• CREB
  View All» Product Name: MILLIPLEX MAP Total CREB MAPmate View All» Analytes Available: CREB, CREB (Total) View All» Configuration: Single Plex View All» Components:
  • Anti-CREB Beads

  • Anti-CREB, Biotin
    View All» UniProt Number: P16220 View All» Panel Type: Cell Signaling View All» Detection Methods:
    • Fluorescent

    • Luminex xMAP
      View All» Packaging: Kit capacity: 100 Assay Points View All» Entrez Gene Number:
      • NM_004379.2

      • NM_134442.2
        View All»
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