货号：46-641

品牌：Merck Millipore

规格：EA

目录价：￥3253.00

市场价格：￥2765.05

会员价格：￥2602.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MILLIPLEX MAP Phospho STAT5A/B (Tyr694/699) MAPmate View All» Trade Name: MILLIPLEX View All» Qty/Pk: 1 kit View All» Product Overview: Optimal antibody pair for detection of STAT5A phosphorylated on Tyr694 and STAT5B phosphorylated on Tyr699. To be used in conjunction with the MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (48-602). View All» Key Applications: Multiplexing View All» Application Notes: The MILLIPLEX MAP Phospho STAT5A/B (Tyr694/699) MAPmates pair is used in conjunction with the MILLIPLEX MAP Cell Signaling Buffer and Detection Kit (Catalog # 48-602) to detect the presence of phosphorylated STAT5A/B (Tyr694/699) in cell lysates using the Luminex® 100 IS, 200, or HTS system. View All» Species Reactivity: Human View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. View All» UniProt Summary: FUNCTION: SwissProt: P51692 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.SIZE: 787 amino acids; 89866 Da SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity).PTM: Tyrosine phosphorylated (By similarity).DISEASE: SwissProt: P51692 # Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.SIMILARITY: SwissProt: P51692 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain. View All» Brand Family: Upstate View All» Storage Conditions: 1 year at 4°C View All» Gene Symbol:

• STAT5A

• MGF

• STAT5
  View All» Product Name: MILLIPLEX MAP Phospho STAT5A/B (Tyr694/699) MAPmate View All» Analytes Available: STAT5A/B, STAT5A/B (Tyr694/699) View All» Configuration: Single Plex View All» Components:
  • Anti-STAT5A/B Beads

  • Anti-Phospho-STAT5A/B (Tyr694/699), Biotin
    View All» UniProt Number:
    • P42229

    • P51692
      View All» Panel Type: Cell Signaling View All» Detection Methods:
      • Fluorescent

      • Luminex xMAP
        View All» Packaging: 100 assay points View All» Entrez Gene Number: NM_003152.2 View All»
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