货号：48-612MAG

品牌：Merck Millipore

规格：

目录价：￥36175.00

市场价格：￥30748.75

会员价格：￥28940.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MILLIPLEX MAP Total Akt/mTOR Magnetic Bead 11-Plex Kit, 48-612MAG View All» Trade Name: MILLIPLEX View All» Qty/Pk: 1 kit View All» Product Overview: The Akt signaling pathway, one of the most often dysregulated signaling pathways in cancer, plays an important role in mediating a very broad range of cellular processes such as growth and development, cell cycle, energy homeostasis, and cell survival. Akt, a serine/threonine kinase that phosphorylates over 100 protein substrates, mediating cell survival and proliferation signals, is often itself hyperphosphorylated in various tumor types. Although the Akt gene itself is not known to be mutated in cancers, many of the upstream regulators of Akt, including IR, IRS, PI3K and PTEN, are oncogenes and tumor suppressors. Downstream of Akt, the mammalian Target Of Rapamycin (mTOR) complex is a key regulator of growth and metabolism. As nearly all of the players in the Akt/mTOR signaling pathway are coordinately regulated by phosphorylation, understanding the role of this pathway in normal physiological processes and in diseases such as cancer and diabetes requires the ability to simultaneously measure phosphorylation status of multiple protein targets. View All» Key Applications: Multiplexing View All» Application Notes: • An overnight (4°C) incubation is recommended for best results.• This assay requires 25 µL diluted cell lysate per well.• This kit must be run using Assay Buffer 2 (provided).• The suggested working range of protein concentration for the assay is 15 to 150 ng of total protein/well (25 μL/well at 600 to 6,000 ng/mL). View All» Species Reactivity: Human View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Storage Conditions: Recommended storage for kit components is 2 - 8°C. View All» Product Name: MILLIPLEX MAP Total Akt/mTOR Magnetic Bead 11-Plex Kit, 48-612MAG View All» Specificity: Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible. View All» Analytes Available: Akt (Total), GSK3α (Total), GSK3β (Total), IGF-1R (Total), IR (total), IRS1 (Total), PTEN (Total), RPS6 (Total), TSC2 (Total), mTOR (Total), p70S6K (Total) View All» Configuration: Premixed View All» Panel Type: Cell Signaling View All» Precision, %:

• Intra-Assay:

• Inter-Assay:
  View All» Detection Methods: Luminex xMAP View All» Packaging: 96-well plate View All»
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