货号：48-615MAG

品牌：Merck Millipore

规格：

目录价：￥15286.00

市场价格：￥12993.10

会员价格：￥12228.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MILLIPLEX MAP Heat Shock Protein Magnetic Bead 5-Plex Kit, 48-615MAG View All» Trade Name: MILLIPLEX View All» Qty/Pk: 1 kit View All» Product Overview: Heat shock proteins (HSPs) are a family of proteins that function as molecular chaperones within the cell, and have many important roles including folding nascent proteins and maintaining proteins in a folded, active state. They can be induced in response to a variety of stresses including heat shock, radiation, and cytotoxic drug exposure, and have increased expression in cancer cells relative to normal cells. A number of these proteins are being investigated as potential targets for cancer therapy, as they can have effects on proliferation, apoptosis, metastasis, and chemotherapy resistance in certain cancers. The levels of some of the family members are coordinately regulated by the transcription factor Heat Shock Factor 1 (HSF1), in response to a variety of cellular stresses. Interestingly, HSP90 inhibitors can disrupt the interaction of HSP90 with HSF1, which can lead to increased expression of HSP family members such as HSP70 and influence the efficacy of treatment. To better understand the roles and regulation of heat shock proteins and the heat shock response in cancer and other physiological processes, there is increased interest in simultaneous analysis of key heat shock proteins in a panel or multiplex format, rather than studying each protein in isolation. View All» Key Applications: Multiplexing View All» Application Notes: • An overnight (4°C) incubation is recommended for best results.• This assay requires 25 µL diluted cell lysate per well.• This kit must be run using Assay Buffer 1 (provided).• The suggested working range of protein concentration for the assay is 15 to 150 ng of total protein/well (25 μL/well at 600 to 6,000 ng/mL). View All» Species Reactivity: Human View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Storage Conditions: Recommended storage for kit components is 2 - 8°C. View All» Product Name: MILLIPLEX MAP Heat Shock Protein Magnetic Bead 5-Plex Kit, 48-615MAG View All» Specificity: Cross-reactivity between the antibodies and any of the other analytes in this panel is non-detectable or negligible. View All» Analytes Available: HSP27 (Total), HSP27 (pS78/pS82), HSP60, HSP70, HSP90α View All» Configuration: Premixed View All» Panel Type: Cell Signaling View All» Detection Methods: Luminex xMAP View All» Packaging: 96-well plate View All»