货号：62-114

品牌：Merck Millipore

规格：

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: siRNA plasmid, pKD-IGF-IR-v2 View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 5 µg View All» Product Overview: mammalian siRNA expression plasmid View All» Key Applications: RNAi/siRNA/Gene Knockdown View All» Application Notes: High transfection efficiency is required for proper performance of this product. View All» Species Reactivity: Human View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. View All» UniProt Summary: FUNCTION: SwissProt: P08069 # This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade.SIZE: 1367 amino acids; 154793 Da SUBUNIT: Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed in a variety of tissues.PTM: The cytoplasmic domain of the beta subunit is autophosphorylated on tyrosine residues in response to insulin- like growth factor I (IGF I). & Phosphorylation of Tyr-980 is required for IRS1- and SHC1- binding.DISEASE: SwissProt: P08069 # Defects in IGF1R may be a cause in some cases of resistance to insulin-like growth factor 1 (IGF1 resistance) [MIM:270450]. IGF1 resistance is a gowth deficiency disorder characterized by intrauterine growth retardation and poor postnatal growth accompanied with increased plasma IGF1.SIMILARITY: SwissProt: P08069 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. & Contains 3 fibronectin type-III domains. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Sales Restrictions: This product is not available for sale in Japan. View All» Presentation: eluted and packaged aseptically in 50μl of 10mM Tris-HCl, pH 8.0, 1mM EDTA View All» Storage Conditions: 5 years at either 4°C or -20°C View All» Gene Symbol:

• IGF1R

• MGC142170

• MGC142172

• IGFIR

• MGC18216

• JTK13

• CD221
  View All» Product Name: siRNA plasmid, pKD-IGF-IR-v2 View All» UniProt Number: P08069 View All» Entrez Gene Number: NM_000875.3 View All» Gene Target: IGF-IR View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：https://www.16ao.com/thread-150769.htm
  © Merck Millipore代理62-114 PKD-IGF-IR-V2 5 UG；该产品已停产，产品报价联系微信jinshanbio