金山科研平台，产品价格货期咨询微信：jinshanbio Assay Type:ELISA Development Kit Assay Length:4 hours 40 minutes (after plate preparation) Sample Type & Volume Required:100 µL Sufficient Materials:For fifteen 96-well plates* Range:31.2 - 2,000 pg/mL Specificity:Please see the product datasheet Molecule Information: TIMP-1 Long Name: Tissue Inhibitors of Metalloproteinases 1 Entrez Gene IDs: 7076 (Human); 21857 (Mouse); 116510 (Rat) Background: TIMPs TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.