货号：AB10130

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NR1D1 (Rev-ErbA α) Antibody | AB10130 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes NR1D1 near the N-terminus. View All» Molecular Weight: ~67 kDa View All» Epitope: Near N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to residues surrounding the area near the N-terminus region of NR1D1. View All» Background Information: Rev-ErbA alpha (NR1D1 or nuclear receptor subfamily 1, group D, member 1), is a member of the Rev-ErbA family of nuclear receptors and is a transcriptional repressor. In mammals, Rev-Erbα is highly expressed in the liver, skeletal muscle, adipose tissue, and the brain, participating in the development and circadian regulation of these tissues. Rev-Erbα regulates gene transcription by directly binding to target response elements (RevREs), comprises an A/T-rich flank followed by AGGTCA. Rev-Erbα mediates repression by recruiting the corepressor N-CoR, which then activates the histone deacetylase (HDAC) 3. A number of target genes has been identified for Rev-Erbα, including the lipoproteins ApoA1 and ApoCIII, hydratase dehydrogenase, the circadian factor BMAL, and the anti-fibrinolytic factor PAI-1. Many of these genes are coordinately regulated by Rev-erbα and the RAR-related orphan receptor RORα, which share the same response elements but exert opposite effects on gene transcription. Crosstalk between Rev-Erbα and RORα likely acts to fine-tune of their target physiologic networks, such as circadian rhythms, metabolic homeostasis, and inflammation. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. Mouse and rat (92% sequence homology). View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected NR1D1 in 10 µg of A431 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.150 mM NaCl and 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for 1 year from date of receipt. View All» UniProt Number: P20393 View All» Entrez Gene Number: NP_068370 View All» Gene Symbol:

• EAR1

• HREV

• Rev-ErbAalpha

• Rev-erbA-alpha

• THRA1

• THRAL

• ear-1

• hRev
  View All» Alternate Names:
  • V-erbA-related protein EAR-1

  • nuclear receptor subfamily 1, group D, member 1

  • thyroid hormone receptor, alpha-like
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Functions as a constitutive transcriptional repressor. Possible receptor for triiodothyronine. SUBUNIT STRUCTURE: Interacts with C1D By similarity.SUBCELLULAR LOCATION: Nucleus Potential. TISSUE SPECIFICITY: Expressed in all tissues and cell lines examined. Expressed at high levels in some squamous carcinoma cell lines. DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR1 subfamily.Contains 1 nuclear receptor DNA-binding domain. View All» Product Name: Anti-NR1D1 (Rev-ErbA α) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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