货号：AB10211

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MSX2 Antibody | AB10211 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptided selected from human MSX2. View All» Molecular Weight: ~29 kDa View All» Immunogen: Synthetic human MSX2 peptide, a.a. 147-164. View All» Background Information: MSX2, also known as HOX-8, is a homeobox containing transcription factor, which is a member of the MSH family of homeobox proteins, and is expressed at sites of epithelial-mesenchymal interaction during embryogenesis. More specifically, MSX2 has been found to be expressed in the epidermis, hair follicles, and fibroblasts of the developing fetal skin, and is detected as a diffuse cytoplasmic signal in fetal epidermis and portions of the hair follicle and dermis. In adult epidermis, however, MSX2 expression is localized to the nucleus. More recently, when in combination with another homeobox gene, MSX1, MSX2 has been shown to play a critical role in the developmental stages of both neural tube and neural crest, suggesting that both the MSX1 and the MSX2 genes play an important role in organogenesis. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Reacts with human and mouse. Comparison of sequence homology suggests that this antibody may also react with rat; however, reactivity with other species has not been tested. View All» Application Notes: Western Blotting: Recommended working dilutions are 1:125 – 1:250. View All» Quality Assurance: Routinely evaluated by Western blot on HeLa cell lysates. View All» Presentation: Purified rabbit polyclonal in buffer containing PBS with 0.09% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles. View All» UniProt Number: P35548 View All» Entrez Gene Number: NM_002449.4 View All» Gene Symbol:
  • HOX8

  • Hox-8

  • MSH

  • FPP

  • CRS2

  • PFM
    View All» Alternate Names:
    • msh homeo box 2

    • msh homeobox 2

    • msh homeobox homolog 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). SUBUNIT: Interacts with MINT (By similarity). Interacts with G22P1 (Ku70) and XRCC5 (Ku80). SUBCELLULAR LOCATION: Nucleus. DISEASE: Defects in MSX2 are the cause of parietal foramina 1 (PFM1) [MIM:168500]; also known as foramina parietalia permagna (FPP). PFM1 is an autosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month. DISEASE: Defects in MSX2 are the cause of parietal foramina with cleidocranial dysplasia (PFMCCD) [MIM:168550]; also known as cleidocranial dysplasia with parietal foramina. PFMCCD combines skull defects in the form of enlarged parietal foramina and deficient ossification of the clavicles. DISEASE: Defects in MSX2 are the cause of craniosynostosis type 2 (CRS2) [MIM:604757]; also known as craniosynostosis Boston-type (CSB). CRS2 is an autosomal dominat disorder characterized by the premature fusion of calvarial sutures. The craniosynostosis phenotype is either fronto-orbital recession, or frontal bossing, or turribrachycephaly, or cloverleaf skull. Associated features include severe headache, high incidence of visual problems (myopia or hyperopia), and short first metatarsals. Intelligence is normal. SIMILARITY: Belongs to the Msh homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain. View All» Product Name: Anti-MSX2 View All» Concentration: 0.25 mg/ml View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-151395.htm
      © Merck Millipore代理AB10211 ANTI-MSX2，产品报价联系微信jinshanbio