货号：AB10302

品牌：Merck Millipore

规格：

目录价：￥4239.00

市场价格：￥3603.15

会员价格：￥3391.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PXR Antibody | AB10302 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 50kDa View All» Immunogen: Recombinant human hPXR View All» Isotype: IgG2b View All» Background Information: Pregnane X receptor (PXR) is a nuclear receptor and is similar in form to PPAR and RXR. PXR is activated by a large number of endogenous and exogenous chemicals including steroids and antibiotics. One of the key roles of PXR is the induction of CYP3A4, an P450 enzyme that is responsible for the metabolism of many drugs. View All» Species Reactivity: Human View All» Application Notes: Suggested dilutions: Western Blot: 1:5000 View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: Raw rabbit serum with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C for up to 12 months from date of receipt. View All» UniProt Number: O75469 View All» Entrez Gene Number:

• NM_003889.3

• NM_022002.2

• NM_033013.2
  View All» Gene Symbol:
  • NR1I2

  • PAR

  • PRR

  • SAR

  • ONR1

  • PAR1

  • BXR

  • SXR

  • PXR

  • PAR2

  • PARq
    View All» Alternate Names: Pregnane X receptor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. View All» UniProt Summary: FUNCTION: SwissProt: O75469 # Orphan receptor; its natural ligand is probably pregnane. Binds to a response element in the CYP3A4 and ABCB1/MDR1 genes promoter. Activates its expression in response to a wide variety of endobiotics and xenobiotics.SIZE: 434 amino acids; 49762 Da SUBUNIT: Forms a heterodimer with RXR.SUBCELLULAR LOCATION: Nucleus (By similarity).TISSUE SPECIFICITY: Expressed in liver, colon and small intestine.SIMILARITY: SwissProt: O75469 ## Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain. View All» Brand Family: Chemicon View All» Product Name: Anti-PXR Antibody | AB10302 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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