货号：AB10305

品牌：Merck Millipore

规格：50UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FXR-B Antibody | AB10305 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 56kDa View All» Immunogen: Recombinant human hFXR-B View All» Isotype: IgG2b View All» Background Information: The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and is known to play a key role in bile acid homeostasis. It does through the regulation of key genes involved in bile acid synthesis, metabolism and transport. View All» Species Reactivity: Human View All» Application Notes: Suggested dilutions: Western Blot: 1:5000 View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: Raw rabbit serum with 0.1% sodium azide. View All» Storage Conditions: Maintain at 2-8°C for up to 12 months from date of receipt. View All» UniProt Number: Q96RI1 View All» Entrez Gene Number: NM_005123.2 View All» Gene Symbol:

• NR1H4

• HRR1

• MGC163445

• FXR

• HRR-1

• RIP14

• BAR

• FXRA
  View All» Alternate Names: farnesoid X receptor View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: Q96RI1 # Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus.SIZE: 486 amino acids; 55914 Da SUBUNIT: Heterodimer of NR1H4 and RXR. Interacts with CARM1 and SMARD1.SUBCELLULAR LOCATION: Nucleus (Probable).SIMILARITY: SwissProt: Q96RI1 ## Belongs to the nuclear hormone receptor family. NR1 subfamily. & Contains 1 nuclear receptor DNA-binding domain. View All» Brand Family: Chemicon View All» Product Name: Anti-FXR-B Antibody | AB10305 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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