货号：AB10317

品牌：Merck Millipore

规格：

目录价：￥3475.00

市场价格：￥2953.75

会员价格：￥2780.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cytochrome P450 CYP450 2C9 Antibody | AB10317 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 56 kDa View All» Epitope: AA 254 to 300 View All» Immunogen: Recombinant human CYP450 2C9 View All» Background Information: P450s are the major enzymes involved in drug metabolism. CYP2C9 makes up about 18% of the cytochrome P450 protein in liver microsomes. Some 100 therapeutic drugs are metabolized by CYP2C9, including drugs with a narrow therapeutic index such as warfarin and phenytoin and other routinely prescribed drugs such as acenocoumarol tolbutamide, losartan glipizide, and some nonsteroidal anti-inflammatory drugs. By contrast, the known extrahepatic CYP2C9 often metabolizes important endogenous compound such as arachidonic acid , 5-hydroxytryptamine and linoleic acid. View All» Species Reactivity: Human View All» Application Notes: Suggested dilutions: Western Blot: 1:2000 View All» Quality Assurance: Routinely evaluated by Western Blot View All» Presentation: Raw rabbit serum with 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C for up to 12 months from date of receipt. View All» UniProt Number: P11712 View All» Entrez Gene Number: NM_000771 View All» Gene Symbol:

• CPC9

• CYP2C

• CYPIIC9

• MGC149605

• MGC88320

• OTTHUMP00000020135

• P450IIC9
  View All» Alternate Names:
  • Cytochrome P450 CYP450 2C9

  • cytochrome P-450 S-mephenytoin 4-hydroxylase

  • cytochrome P450, family 2, subfamily C, polypeptide 9

  • cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase),polypeptide 9

  • cytochrome p4502C9

  • flavoprotein-linked monooxygenase

  • mephenytoin 4-hydroxylase

  • microsomal monooxygenase

  • xenobiotic monooxygenase
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq] View All» UniProt Summary: Function: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.Catalytic activity: (+)-(R)-limonene + NADPH + O(2) = (+)-trans-carveol + NADP(+) + H(2)O.(-)-(S)-limonene + NADPH + O(2) = (-)-trans-carveol + NADP(+) + H(2)O.(-)-(S)-limonene + NADPH + O(2) = (-)-perillyl alcohol + NADP(+) + H(2)O.Cofactor: Heme group.Subcellular location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Induction: By rifampicin.Sequence similarities: Belongs to the cytochrome P450 family. View All» Brand Family: Chemicon View All» Product Name: Anti-Cytochrome P450 CYP450 2C9 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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