货号：AB10337

品牌：Merck Millipore

规格：

目录价：￥4739.00

市场价格：￥4028.15

会员价格：￥3791.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MDR1b Antibody, ATP Binding Cassette Sub family B | AB10337 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Chemicon (Millipore) View All» Molecular Weight: 141 kDa View All» Epitope: AA E632 – T744 View All» Immunogen: Recombinant rat MDR1b View All» Background Information: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier View All» Species Reactivity: Rat View All» Application Notes: Western Blot: 1:5000 View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Presentation: Raw rabbit serum with 0.05% sodium azide. View All» Storage Conditions: Maintain at -20°C for up to 12 months from date of receipt. View All» UniProt Number: P43245 View All» Entrez Gene Number: NM_012623 View All» Gene Symbol:

• EC 3.6.3.44

• ATP-binding cassette sub-family B member 1

• P-glycoprotein 1

• CD243 antigen
  View All» Alternate Names: MDR1b, ATP Binding Cassette Sub family B View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: member of the ATP-binding cassette (ABC) protein superfamily; may play a role in drug disposition View All» UniProt Summary: FUNCTION: SwissProt: P43245# Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. SIZE: 1277 amino acids; 141387 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.SIMILARITY: SwissProt: P43245# Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily View All» Brand Family: Chemicon View All» Product Name: Anti-MDR1b Antibody, ATP Binding Cassette Sub family B | AB10337 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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