货号：AB10406

品牌：Merck Millipore

规格：EA

目录价：￥3108.00

市场价格：￥2641.80

会员价格：￥2486.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TRAM1 Antibody | AB10406 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes TRAM1. View All» Molecular Weight: ~36 kDa observed (43 kDa calculated molecular weight). Western blot analysis shows that TRAM1 is an abundantly expressed, approximately 36 kDa microsomal glycoprotein. Functional analysis indicated that TRAM influences glycosylation and is stimulatory or required for the translocation of secretory proteins (Oresic, K., et al. JBC (2009). 284:5905-5914.). View All» Epitope: Internal Domain View All» Immunogen: Linear peptide corresponding to the internal domain of human TRAM1. View All» Background Information: Translocating chain-associated membrane protein 1 (TRAM1) belonging to the TRAM family is a multi-pass membrane protein, a component of the translocon, found within the Endoplasmic Reticulum (ER). TRAM1 functions as a mediator for the lateral movement of specific signaling peptides and transmembrane segments into the membrane bilayer from the translocon. However, TRAM1 is not necessary for all transmembrane proteins to translocate into the ER. Studies indicate a possible role for TRAM1 in dislocating membrane glycoprotein, which would enable TRAM1 to have a dual role in nascent polypeptide processing and ER protein dislocation. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Western Blot (SNAP ID) Analysis: 1 µg/mL of this antibody has been shown to detect TRAM1 in 10 µg of human liver lysate.Immunohistochemistry Analysis: A 1:500 dilution of this antibody has been shown to detect TRAM1 in squamous epithelial carcinoma tissue, with staining patterns restricted to malignant cells. View All» Control: Human liver lysate View All» Quality Assurance: Evaluated by Western Blot in human liver lysate.Western Blot Analysis: 1 µg/mL of this antibody detected TRAM1 in 10 µg of human liver lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15629 View All» Entrez Gene Number: NP_055109 View All» Gene Symbol:

• PRO1292

• TRAM1

• TRAMP1

• PNAS8
  View All» Alternate Names:
  • translocation associated membrane protein 1

  • translocation-associating membrane protein 1

  • translocating chain-associating membrane protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry (Paraffin)
      View All» Entrez Gene Summary: This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Stimulatory or required for the translocation of secretory proteins across the ER membrane.SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. SEQUENCE SIMILARITIES: Belongs to the TRAM family.Contains 1 TLC (TRAM/LAG1/CLN8) domain. View All» Product Name: Anti-TRAM1 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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