货号：AB10410

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-YES (Proto-oncogene c-Yes) Antibody | AB10410 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes YES (Proto-oncogene c-Yes) near the N-terminus. View All» Molecular Weight: ~60 kDa View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of of human YES (Proto-oncogene c-Yes). View All» Background Information: YES (Proto-oncogene c-Yes) is a member of the src protein tyrosine kinase family (SFK), which is involved in the various cellular processes. Of all the SFKs, c-Yes has been found to have the closest relation to c-Src, the family’s archetypal kinase, as they share greater than 80% homology. Researchers have speculated that c-Yes may be involved in protein sorting or vesicular trafficking due to its being the sole SFK present in lipid rafts enriched in caveolin in MDCK cells. Higher levels of c-Yes activities and protein have been observed in melanoma and melanocyte cell lines of human origin. Also, c-Yes has been associated with the promotion of viral infections such as Neisseria gonorrhoeae and west Nile Virus. View All» Species Reactivity:

• Human

• Horse
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with equine (horse) based on 100% sequence homology.Bovine (cow) (93% sequence homology) and canine (dog) (80% sequence homology). View All» Application Notes: Western Blot (SNAP ID) Analysis: 4 µg/mL of this antibody detected YES (Proto-oncogene c-Yes) in 10 µg of A431 cell lysate. View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: 2 µg/mL of this antibody detected YES (Proto-oncogene c-Yes) in 10 µg of A431 cell lysate. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P07947 View All» Entrez Gene Number: NP_005424 View All» Gene Symbol:
  • YES1

  • p61-Yes

  • c-yes

  • P61-YES

  • Yes

  • HsT441

  • YES
    View All» Alternate Names:
    • v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1

    • Yamaguchi sarcoma oncogene

    • viral oncogene yes-1 homolog 1

    • proto-oncogene tyrosine-protein kinase YES
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating MCP/CD46.SIZE: 543 amino acids; 60801 Da SUBCELLULAR LOCATION: Cytoplasm, cytosol. Note=In epithelial cells infected with Neisseria gonorrhoeae, forms aggregates beneath bacterial microcolonies.PTM: Autophosphorylated.SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain. View All» Product Name: Anti-YES (Proto-oncogene c-Yes) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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