货号：AB10439

品牌：Merck Millipore

规格：100Ug

目录价：￥5359.00

市场价格：￥4555.15

会员价格：￥4287.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PACSIN1 Antibody, N-terminus | AB10439 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes human PACSIN1. View All» Molecular Weight: ~57 kDa View All» Epitope: N-terminus View All» Immunogen: KLH conjugated synthetic peptide selected from the N-terminal region of human PACSIN1. View All» Background Information: PACSINs, also known as syndapins, are a protein family consisting of three members that have been implicated in synaptic vesicular membrane trafficking and regulation of dynamin-mediated endocytotic processes (Cuajungco, 2006). It is presumed that all isoforms bind Dynamin, Synaptojanin 1 and N-WASP through their Src homology 3 domains. While PACSIN1 appears to be restricted to neural tissues, two PACSINs are more widespread with PACSIN2 being ubiquitously expressed and PACSIN3 present mainly in skeletal muscle, heart and lung (Modregger, 2001). PACSIN1 has been implicated as playing a central role in synaptic vesicle recycling (Kessels, 2004). Expected molecular weight is 51 kDa. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human and mouse. Reactivity with other species has not been tested. View All» Control: Mouse brain lysate View All» Quality Assurance: Evaluated on a representative lot by Western blot on mouse brain lysate using a 1:100 - 1:500 dilution of Anti-PACSIN1. View All» Purification Method: Protein G purfied View All» Presentation: PBS containing 0.09% NaN3. View All» Storage Conditions: Maintain at 2-8ºC for up to 6 months from date of receipt. -20ºC is recommended for long term storage. View All» UniProt Number: Q9BY11 View All» Entrez Gene Number: Q9BY11 View All» Gene Symbol:
  • KIAA1379

  • OTTHUMP00000016231

  • SDPI
    View All» Alternate Names:
    • protein kinase C and casein kinase substrate in neurons 1

    • syndapin I
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» UniProt Summary: FUNCTION: May play a role in vesicle formation and transport. Ref.6SUBUNIT STRUCTURE: Homo- and hetero-aggregates with other PACSINs. Binds dynamin I, synaptojanin, synapsin I and the neural Wiskott-Aldrich syndrome protein (N-WASP) By similarity.SUBCELLULAR LOCATION: CytoplasmBy similarity. Note= Colocalizes with dynamin I at vesicular structures in the cell body and neurites By similarity.TISSUE SPECIFICITY: Highly expressed in brain and in a lesser extent in heart, pancreas and liver.PTM: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC) Probable.SEQUENCE SIMILARITIES: Belongs to the PACSIN family.Contains 1 FCH domain.Contains 1 SH3 domain. View All» Product Name: Anti-PACSIN1, N-terminus View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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