货号：AB10514P

品牌：Merck Millipore

规格：100Ug

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Serotonin Transporter Antibody | AB10514P View All» Replaces: AB1594P View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody reacts with the 70 kDa serotonin transporter protein. View All» Molecular Weight: 70 kDa View All» Epitope: Center region View All» Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human serotonin transporter. View All» Background Information: This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. View All» Species Reactivity:

• Mouse

• Human

• Rat
  View All» Species Reactivity Note: Reacts with human, mouse and rat. Other species have not been tested. 100% homology to human, monkey, chimp, horse, mouse, rat, cow, sheep. View All» Control: Western Blot : Human lung lysate. View All» Quality Assurance: Western Blot Analysis: 1:1000 dilution of this antibody detected serotonin transporter on human lung lysate. View All» Purification Method: Antigen affinity purified View All» Presentation: Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. View All» Storage Conditions: Store at 2-8°C for 1 year from date of receipt. View All» UniProt Number: P31645 View All» Gene Symbol:
  • 5-HTT

  • 5HTT

  • HTT

  • OCD1

  • SERT

  • hSERT
    View All» Alternate Names:
    • solute carrier family 6 (neurotransmitter transporter,serotonin), member 4

    • sodium-dependent serotonin transporter

    • serotonin transporter

    • Solute carrier family 6 member 4

    • Na+/Cl- dependent serotonin transporter

    • 5HT transporter

    • 5-hydroxytryptamine transporter
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals.SUBUNIT STURCTURE: Interacts with TGFB1I1. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. POLYMORPHISM: A polymorphism in the promoter region (5-HTT gene-linked polymorphic region, 5-HTTLPR) is located approximately 1 kb upstream of the transcription initiation site and is composed of 16 repeat elements. The polymorphism consists of a 44-bp insertion or deletion involving repeat elements 6 to 8. The short allele is associated with lower transcriptional efficiency of the promoter compared with the long allele. Over half of the Caucasian population has a short allele. Individuals with one or two copies of the short allele exhibit more depressive symptoms, diagnosable depression and suicidality in relation to stressful life events than individuals homozygous for the long allele.The polymorphism Val-425 seems to be linked to a susceptibility to obsessive-compulsive disorder (OCD) [MIM:164230].Genetic variations in SLC6A4 determine the genetic susceptibility to alcoholism [MIM:103780].MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.SEQUENCE SIMILARITIES: Belongs to the sodium:neurotransmitter symporter (SNF) family. View All» Product Name: Anti-Serotonin Transporter View All» Concentration: 1 mg/ml View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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