货号：AB10520

品牌：Merck Millipore

规格：100UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DAP-5 Antibody | AB10520 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes DAP-5. View All» Molecular Weight: 97 kDa View All» Epitope: Unknown View All» Immunogen: KLH-conjugated linear peptide corresponding to human DAP-5. View All» Isotype: IgG View All» Background Information: Death Associated Protein 5 (DAP-5) is a protein with high amino acid sequence homology to Eukaryotic Translation Initiation Factor 4G (eIF4G). Compared with eIF4G, DAP5 lacks the N-terminal region necessary for cap-dependent translation and has a unique C-terminal part functioning as a regulator for interferon-gamma induced cell death. DAP5 is cleaved at Asp790 during apoptosis . The C-terminal truncated form of DAP5 functions as a cap-independent translation initiation factor responsible for the mediation of its own translation during apoptosis. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Proven to react with human and mouse. Predicted to react with rat based on 100% sequence homology. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot on Jurkat cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected DAP-5 on 10 µg of jurkat cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P78344 View All» Entrez Gene Number: NP_001036024.1 View All» Gene Symbol:
  • EIF4G2

  • AAG1

  • DAP-5

  • DAP5

  • NAT1

  • p97
    View All» Alternate Names:
    • Death-associated protein 5

    • aging-associated protein 1

    • eIF-4-gamma 2

    • eIF-4G 2

    • eIF4G 2

    • eukaryotic translation initiation factor 4 gamma, 2

    • eukaryotic translation initiation factor 4G-like 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G that contains the binding sites for eIF4A and eIF3; eIF4G, in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G, which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. In vitro and in vivo studies indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. Alternatively spliced transcript variants encoding different isoforms of this gene have been described. [provided by RefSeq] View All» UniProt Summary: FUNCTION: Appears to play a role in the switch from cap-dependent to IRES-mediated translation during mitosis, apoptosis and viral infection. Cleaved by some caspases and viral proteases. SUBUNIT STRUCTURE: Interacts with the serine/threonine protein kinases MKNK1 and MKNK2. Binds EIF4A and EIF3. Interacts with MIF4GD. TISSUE SPECIFICTY: Ubiquitously expressed in all adult tissues examined, with high levels in skeletal muscle and heart. Also expressed in fetal brain, lung, liver and kidney.PTM: Phosphorylation; hyperphosphorylated during mitosis. MISCELLANEOUS: This gene has been shown to be extensively edited in the liver of APOBEC1 transgenic animal model. Its aberrant editing could contribute to the potent oncogenesis induced by overexpression of APOBEC1. The aberrant edited sequence, called NAT1, is likely to be a fundamental translational repressor.SEQUENCE SIMILARITIES: Belongs to the eIF4G family.Contains 1 MI domain.Contains 1 MIF4G domain.Contains 1 W2 domain. View All» Product Name: Anti-DAP-5 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-151494.htm
      © Merck Millipore代理AB10520 Anti-DAP-5 Antibody;store at -20℃，产品报价联系微信jinshanbio