货号：AB10521

品牌：Merck Millipore

规格：100UL

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neuropilin-1 Antibody | AB10521 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Neuropilin-1. View All» Molecular Weight: 130 kDa View All» Epitope: Unknown View All» Immunogen: This antibody is generated from rabbits immunized with a His-tagged partial recombinant rat Neuropilin-1. View All» Isotype: IgG View All» Background Information: Neuropilin-1 is a type 1 membrane protein with three distinct functions. First, it can mediate cell adhesion via a heterophilic molecular interaction. Second, in neuronal cells, neuropilin-1 binds the class 3 semaphorins, which are neuronal chemorepellents, and plays a role in the directional guidance of axons. It is expected to form complexes with the plexinA subfamily members and mediate the semaphorin-elicited inhibitory signals into neurons. Third, in endothelial cells, neuropilin-1 binds a potent endothelial cell mitogen, vascular endothelial growth factor (VEGF)165, and regulates vessel formation. View All» Species Reactivity:

• Rat

• Mouse
  View All» Species Reactivity Note: Proven to react with mouse and rat. Human-94% homology View All» Control: PC12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC12 cell lysate.Western Blot Analysis: : 1:1,000 dilution of this antibody detected Neuropilin 1 on 10 µg of PC12 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit serum in buffer containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q9QWJ9 View All» Entrez Gene Number: NP_659566.1 View All» Gene Symbol:
  • NRP1

  • NRP

  • NP1

  • BDCA4

  • CD304

  • neuropilin-1
    View All» Alternate Names:
    • CD304 antigen

    • Vascular endothelial cell growth factor 165 receptor

    • neuropilin 1

    • transmembrane receptor

    • Npn 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry

      • Immunoprecipitation

      • Immunofluorescence
        View All» Entrez Gene Summary: NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM] View All» UniProt Summary: FUNCTION: Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis (By similarity).SUBUNIT: Heterodimer with NRP2 (Probable). Binds PLXNB1 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Found in the embryonic nervous system.SIMILARITY: Belongs to the neuropilin family.Contains 2 CUB domains. Contains 2 F5/8 type domains. Contains 1 MAM domain. View All» Product Name: Anti-Neuropilin-1 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Target / Localization: Plasma membrane View All» Format: Serum View All» Host: Rabbit View All»
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