货号：AB10527

品牌：Merck Millipore

规格：100Ug

目录价：￥4563.00

市场价格：￥3878.55

会员价格：￥3650.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-VDAC Antibody | AB10527 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~33 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human VDAC. View All» Background Information: Voltage-dependent anion-selective channel protein 1 (also known as VDAC, VDAC1 or outer mitochondrial membrane protein porin 1) is the the outer mitochondrial membrane receptor for hexokinase and BCL2L1. VDAC forms a channel through the mitochondrial membrane and is involved in small molecule diffusion, cell volume regulation and apoptosis. VDAC may participate in the formation of the permeability transition pore complex (PTPC), which is responsible for the release of mitochondrial products that triggers apoptosis. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine

• Horse

• Rhesus Macaque

• Chimpanzee

• Pig
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. Predicted to react with bovine, equine, rhesus macaque, chimpanzee, and porcine based on 100% sequence homology. View All» Control: HepG2 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HepG2 cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected VDAC in 10 µg of HepG2 cell lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P21796 View All» Entrez Gene Number: NP_003365 View All» Gene Symbol:
  • VDAC1

  • VDAC

  • PORIN1

  • hVDAC1
    View All» Alternate Names:
    • voltage-dependent anion channel 1

    • Porin 31HL

    • Outer mitochondrial membrane protein porin 1

    • PORIN-31-HL

    • Porin 31HM

    • voltage-dependent anion-selective channel protein 1

    • Plasmalemmal porin
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y. View All» UniProt Summary: FUNCTION: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. SUBUNIT STRUCTURE: Interacts with hexokinases By similarity. Interacts with BCL2L1. Interacts with influenza A virus PB1-F2 protein. SUBCELLULAR LOCATION: Mitochondrion outer membrane. Cell membrane TISSUE SPECIFICTY: Heart, liver and skeletal muscle.DOMAIN: Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands. The helical N-terminus folds back into the pore opening and plays a role in voltage-gated channel activity.SEQUENCE SIMILARITIES: Belongs to the eukaryotic mitochondrial porin family. View All» Product Name: Anti-VDAC View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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