货号：AB10533

品牌：Merck Millipore

规格：100UL

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-LMX-1 Antibody | AB10533 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes LMX-1. View All» Molecular Weight: ~50 kDa observed. View All» Epitope: C-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to the C-terminus of hamster LMX-1. View All» Isotype: IgG View All» Background Information: LMX-1 is a transcription factor that belongs to the LIM-homeodomain (LIM-HD) transcription factor family. It is induced within the ventral midbrain as a response to early signaling. LMX-1 is a necessary component for the development of the roof plate and for CNS dorsal cell date specification and the development of vertebrae. It is Expressed in roof plate, an organizational locus found in the dorsal CNS that functions to moderate the differentiation and specification of adjacent neurons through the secretion of signaling molecules such as WNT and BMP. Recent studies have indicated that LMX-1 has high potential for stimulating the production of mesencephalic dopamine neurons(mesDA) for the therapeutic treatment Parkinson disease, a condition characterized by dopaminergic neurotransmission decline resulting from the progression of mesDA neuronal degeneration within the substantia nigra pars compacta (SN). View All» Species Reactivity:

• Mouse

• Rat

• Hamster
  View All» Species Reactivity Note: Demonstrated to react with mouse and rat. Predicted to react with hamster based on 100% sequence homology. View All» Control: Mouse testis tissue lysate View All» Quality Assurance: Evaluated by Western Blot in mouse testis tissue lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected LMX-1 on 10 µg of mouse testis tissue lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified rabbit polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q04650 View All» Entrez Gene Number: AAB62320 View All» Gene Symbol:
  • LMX-12

  • LMX1.1

  • LMX-1.1

  • LMX1
    View All» Alternate Names:
    • LIM homeobox transcription factor 1, alpha

    • LIM/homeobox protein 1.1

    • LIM/homeobox protein LMX1A
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity).SUBCELLULAR LOCATION: Nucleus. SEQUENCE SIMILARITIES: Contains 1 homeobox DNA-binding domain.Contains 2 LIM zinc-binding domains. View All» Product Name: Anti-LMX-1 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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